HitPredict

Interactor 1: SC22B (O75396)
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
Gene: SEC22B

Interactor 2: SNAA (P54920)
Alpha-soluble NSF attachment protein (SNAP-alpha) (N-ethylmaleimide-sensitive factor attachment protein alpha)
Gene: NAPA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.80	0.813

Property	Details
Experiments	30833792, 35271311, 28514442, 33961781
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SNAP~Synaptobrevin
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 295
+	Dm
		115802 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Hs
		850546 VAMP7_HUMAN (31-198): 2.63e-62: 195: 22.62		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Dm
		1095560 Q7JYX5_DROME (30-214): 7.52e-63: 196: 20.54		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Hs
		180842 YKT6_HUMAN (30-188): 3.07e-53: 171: 23.13		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Zm
		31296 A0A1D6KH00_MAIZE (25-215): 2.1e-70: 227: 18.65		A0A1D6PZ82_MAIZE (5-272): 3.97e-89: 271: 36.80
+	Hs
		263338 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Sc
		605825 SEC22_YEAST (1-215): 1.97e-66: 205: 35.65		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Dm
		1095592 Q9W3M8_DROME (28-188): 3.61e-45: 150: 20.25		SNAP_DROME (5-295): 7.84e-105: 308: 61.51
+	Dm
		115822 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Hs
		111025 I1VE18_HUMAN (63-115): 1.09e-21: 85.8: 98.11		SNAA_HUMAN (1-295): 2.13e-113: 330: 100.00
+	Sc
		696563 YKT6_YEAST (31-188): 1.64e-44: 148: 24.54		SEC17_YEAST (8-294): 4.63e-88: 266: 34.48
+	Hs
		850592 VAMP7_HUMAN (31-198): 2.63e-62: 195: 22.62		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		115828 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53
+	Dm
		1178116 Q7JYX5_DROME (30-214): 7.52e-63: 196: 20.54		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Hs
		180923 YKT6_HUMAN (30-188): 3.07e-53: 171: 23.13		SNAG_HUMAN (4-265): 6.75e-68: 215: 23.40
+	Dm
		1178122 Q7JYX5_DROME (30-214): 7.52e-63: 196: 20.54		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53
+	Dm
		1353755 Q9W3M8_DROME (28-188): 3.61e-45: 150: 20.25		Q9U6R9_DROME (4-265): 3.84e-58: 190: 18.49
+	Dm
		1366632 Q9W3M8_DROME (28-188): 3.61e-45: 150: 20.25		Q9VH25_DROME (18-265): 1.8e-53: 177: 17.53