HitPredict

Interactor 1: SC22B (O75396)
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
Gene: SEC22B

Interactor 2: STX18 (Q9P2W9)
Syntaxin-18 (Cell growth-inhibiting gene 9 protein)
Gene: STX18

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.736

Property	Details
Experiments	28514442, 33961781, 26186194, 15029241, 35271311, 19369418
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005484 - SNAP receptor activity GO:0005789 - endoplasmic reticulum membrane GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0031201 - SNARE complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 335
+	Hs
		850602 VAMP7_HUMAN (31-198): 2.63e-62: 195: 22.62		STX18_HUMAN (1-335): 2.61e-130: 376: 100.00
+	Dm
		115824 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		Q9VC58_DROME (3-333): 4.05e-94: 286: 31.74
+	Dm
		1178117 Q7JYX5_DROME (30-214): 7.52e-63: 196: 20.54		Q9VC58_DROME (3-333): 4.05e-94: 286: 31.74
+	Dm
		1362604 Q9W3M8_DROME (28-188): 3.61e-45: 150: 20.25		Q9VC58_DROME (3-333): 4.05e-94: 286: 31.74
+	Sc
		605857 SEC22_YEAST (1-215): 1.97e-66: 205: 35.65		UFE1_YEAST (46-332): 1.49e-64: 209: 16.15
+	Sc
		731058 YKT6_YEAST (31-188): 1.64e-44: 148: 24.54		UFE1_YEAST (46-332): 1.49e-64: 209: 16.15