HitPredict

Interactor 1: SC22B (O75396)
Vesicle-trafficking protein SEC22b (ER-Golgi SNARE of 24 kDa) (ERS-24) (ERS24) (SEC22 vesicle-trafficking protein homolog B) (SEC22 vesicle-trafficking protein-like 1)
Gene: SEC22B

Interactor 2: VTI1B (Q9UEU0)
Vesicle transport through interaction with t-SNAREs homolog 1B (Vesicle transport v-SNARE protein Vti1-like 1) (Vti1-rp1)
Gene: VTI1B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Synaptobrevin~V-SNARE_C
Common GO terms	GO:0005484 - SNAP receptor activity GO:0005789 - endoplasmic reticulum membrane GO:0012507 - ER to Golgi transport vesicle membrane GO:0031201 - SNARE complex GO:0048280 - vesicle fusion with Golgi apparatus
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 232
+	Hs
		263321 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		VTI1A_HUMAN (7-231): 7.83e-55: 176: 27.56
+	Rn
		192340 SC22B_RAT (1-215): 6.45e-91: 267: 100.00		GOSR2_RAT (11-226): 2.71e-47: 157: 16.44
+	Hs
		151536 SC22B_HUMAN (1-215): 6.45e-91: 267: 100.00		GOSR2_HUMAN (11-226): 4.43e-45: 151: 15.07
+	Dm
		115847 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		Q9W0N6_DROME (9-228): 1.19e-48: 161: 22.27
+	At
		812696 VA722_ARATH (31-199): 6.71e-74: 224: 23.39		NPS11_ARATH (1-214): 9.22e-51: 167: 16.67
+	At
		1276255 VA721_ARATH (31-199): 3.6e-73: 222: 22.81		NPS11_ARATH (1-214): 9.22e-51: 167: 16.67
+	Mm
		291513 VAMP7_MOUSE (31-198): 2.71e-62: 195: 22.02		VTI1B_MOUSE (1-232): 4.49e-61: 193: 92.24
+	Dm
		115839 M9PGI6_DROME (1-215): 2.77e-76: 230: 56.22		GOSR2_DROME (11-226): 3.82e-47: 156: 17.13
+	Hs
		850604 VAMP7_HUMAN (31-198): 2.63e-62: 195: 22.62		VTI1B_HUMAN (1-232): 7.05e-54: 174: 100.00
+	At
		221565 VA711_ARATH (2-197): 6.88e-66: 204: 21.43		VTI11_ARATH (7-230): 1.24e-49: 163: 26.22
+	Dm
		1178140 Q7JYX5_DROME (30-214): 7.52e-63: 196: 20.54		Q9W0N6_DROME (9-228): 1.19e-48: 161: 22.27
+	Dm
		1178131 Q7JYX5_DROME (30-214): 7.52e-63: 196: 20.54		GOSR2_DROME (11-226): 3.82e-47: 156: 17.13
+	Sc
		605872 SEC22_YEAST (1-215): 1.97e-66: 205: 35.65		VTI1_YEAST (7-210): 3.79e-32: 118: 22.33
+	Dm
		1376185 Q9W3M8_DROME (28-188): 3.61e-45: 150: 20.25		Q9W0N6_DROME (9-228): 1.19e-48: 161: 22.27
+	Dm
		1373159 Q9W3M8_DROME (28-188): 3.61e-45: 150: 20.25		GOSR2_DROME (11-226): 3.82e-47: 156: 17.13
+	Sc
		731079 YKT6_YEAST (31-188): 1.64e-44: 148: 24.54		VTI1_YEAST (7-210): 3.79e-32: 118: 22.33