HitPredict

Interactor 1: PR40A (O75400)
Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)
Gene: PRPF40A

Interactor 2: SF3A1 (Q15459)
Splicing factor 3A subunit 1 (SF3a120) (Spliceosome-associated protein 114) (SAP 114)
Gene: SF3A1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.679

Property	Details
Experiments	35271311, 22365833, 16055720
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016607 - nuclear speck GO:0045292 - mRNA cis splicing, via spliceosome and 1 others more... GO:0071004 - U2-type prespliceosome
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 957 Hs			1 793
+	Hs
		154814 TCRG1_HUMAN (6-820): 7.38e-41: 165: 16.47		SF3A1_HUMAN (1-793): 1.4e-107: 349: 100.00
+	Hs
		808632 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		SF3A1_HUMAN (1-793): 1.4e-107: 349: 100.00
+	Hs
		269240 WBP4_HUMAN (102-385): 6.66e-27: 115: 14.68		SF3A1_HUMAN (1-793): 1.4e-107: 349: 100.00
+	Hs
		724842 MYH9_HUMAN (528-957): 1.03e-10: 68.1: 11.11		SF3A1_HUMAN (1-793): 1.4e-107: 349: 100.00
+	Hs
		263765 PR40A_HUMAN (1-957): 5.9e-97: 328: 100.00		PRG4_HUMAN (419-772): 3.6e-10: 66: 13.22
+	Hs
		551790 DESP_HUMAN (419-952): 2.38e-60: 227: 12.98		TITIN_HUMAN (293-702): 3.81e-38: 156: 16.70
+	Sp
		143499 DRE4_SCHPO (139-532): 8.3e-52: 189: 14.89		SA114_SCHPO (23-507): 1.91e-39: 154: 32.38
+	Sc
		477652 URN1_YEAST (186-646): 2.61e-58: 209: 12.87		RL40A_YEAST (722-790): 8.57e-22: 93.5: 30.44
+	Hs
		152609 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		KMT2D_HUMAN (538-699): 7.37e-26: 117: 22.35
+	Hs
		257713 ITSN2_HUMAN (41-720): 9.42e-36: 149: 9.78		ANR17_HUMAN (240-740): 2.15e-26: 118: 11.11
+	Hs
		808486 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		RL40_HUMAN (722-790): 6.93e-24: 99.4: 30.44
+	Hs
		125040 WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86		ANR17_HUMAN (240-740): 2.15e-26: 118: 11.11
+	Hs
		554367 WWP1_HUMAN (22-297): 5.32e-15: 81.7: 13.88		MUC1_HUMAN (253-757): 1.26e-24: 112: 9.32
+	Dm
		113976 M9PB30_DROME (2-350): 4.07e-23: 108: 10.15		M9PB30_DROME (433-757): 1.67e-12: 73.7: 12.57
+	Hs
		924156 WWP1_HUMAN (22-297): 5.32e-15: 81.7: 13.88		RS27A_HUMAN (722-790): 7.14e-21: 92: 30.44
+	Hs
		125347 WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86		RS27A_HUMAN (722-790): 7.14e-21: 92: 30.44
+	Hs
		125274 WWP2_HUMAN (4-227): 1.27e-13: 77.3: 12.86		SC24C_HUMAN (429-746): 1.82e-09: 63.7: 13.13