HitPredict

Interactor 1: PR40A (O75400)
Pre-mRNA-processing factor 40 homolog A (Fas ligand-associated factor 1) (Formin-binding protein 11) (Formin-binding protein 3) (Huntingtin yeast partner A) (Huntingtin-interacting protein 10) (HIP-10) (Huntingtin-interacting protein A) (Renal carcinoma antigen NY-REN-6)
Gene: PRPF40A

Interactor 2: CPSF6 (Q16630)
Cleavage and polyadenylation specificity factor subunit 6 (Cleavage and polyadenylation specificity factor 68 kDa subunit) (CPSF 68 kDa subunit) (Cleavage factor Im complex 68 kDa subunit) (CFIm68) (Pre-mRNA cleavage factor Im 68 kDa subunit) (Protein HPBRII-4/7)
Gene: CPSF6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	24981860, 35271311, 16055720
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 957 Hs			1 551
+	Hs
		263733 PR40A_HUMAN (1-957): 5.9e-97: 328: 100.00		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		154818 TCRG1_HUMAN (6-820): 7.38e-41: 165: 16.47		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		808655 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084649 ITSN2_HUMAN (41-720): 9.42e-36: 149: 9.78		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		269244 WBP4_HUMAN (102-385): 6.66e-27: 115: 14.68		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084573 ITCH_HUMAN (4-297): 3.34e-18: 92.1: 13.95		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		1084614 WWP1_HUMAN (22-297): 5.32e-15: 81.7: 13.88		CPSF6_HUMAN (1-520): 3.7e-92: 294: 100.00
+	Hs
		808408 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		SMCA2_HUMAN (179-551): 2.13e-47: 180: 14.93
+	Hs
		808771 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		808409 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		SMCA4_HUMAN (126-551): 8.83e-45: 172: 15.98
+	Hs
		269254 WBP4_HUMAN (102-385): 6.66e-27: 115: 14.68		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		516402 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		1235773 ITCH_HUMAN (4-297): 3.34e-18: 92.1: 13.95		CPSF7_HUMAN (1-525): 3.55e-48: 175: 40.82
+	Hs
		808925 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		PABP3_HUMAN (82-518): 1.28e-22: 103: 15.56
+	Hs
		808888 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		DIDO1_HUMAN (164-416): 4.81e-09: 61.5: 21.59
+	Hs
		808903 YAP1_HUMAN (34-410): 2.24e-42: 164: 10.05		WDR33_HUMAN (180-396): 5.21e-09: 61.5: 24.69
+	Hs
		269201 WBP4_HUMAN (102-385): 6.66e-27: 115: 14.68		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Hs
		516643 ITCH_HUMAN (4-297): 3.34e-18: 92.1: 13.95		PABP1_HUMAN (81-518): 2.46e-24: 109: 16.40
+	Dm
		113976 M9PB30_DROME (2-350): 4.07e-23: 108: 10.15		M9PB30_DROME (190-412): 1.36e-12: 73: 16.67
+	Sc
		376704 PRP40_YEAST (144-667): 4.38e-18: 91.1: 16.90		PABP_YEAST (82-174): 3.01e-12: 71.1: 27.96