HitPredict

Interactor 1: TACC1 (O75410)
Transforming acidic coiled-coil-containing protein 1 (Gastric cancer antigen Ga55) (Taxin-1)
Gene: TACC1

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	20078863
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0030331 - nuclear estrogen receptor binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 805 Hs			1 595
+	Hs
		369763 CYTSB_HUMAN (69-780): 7.11e-52: 198: 13.92		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		264075 TACC1_HUMAN (1-805): 1.32e-103: 339: 100.00		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		369446 DYST_HUMAN (464-797): 3.16e-33: 141: 9.44		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369804 CYTSA_HUMAN (293-790): 4.43e-33: 139: 11.52		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		368927 MUC1_HUMAN (9-367): 1e-15: 83.8: 12.22		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		370040 KMT2C_HUMAN (5-646): 3.67e-10: 66.1: 7.94		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		1129120 CYTSB_HUMAN (69-780): 7.11e-52: 198: 13.92		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Mm
		509323 TACC1_MOUSE (1-805): 3.45e-81: 278: 70.83		RARA_MOUSE (81-545): 8.36e-104: 323: 22.37
+	Hs
		311824 TACC2_HUMAN (7-804): 1.65e-49: 192: 26.54		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		974119 DYST_HUMAN (464-797): 3.16e-33: 141: 9.44		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1148940 CYTSA_HUMAN (293-790): 4.43e-33: 139: 11.52		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1270066 PCLO_HUMAN (16-688): 2.94e-17: 89.2: 9.54		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		554348 MUC1_HUMAN (9-367): 1e-15: 83.8: 12.22		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1269843 YM012_HUMAN (6-332): 1.06e-10: 67.3: 12.42		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1243831 KMT2C_HUMAN (5-646): 3.67e-10: 66.1: 7.94		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		782595 KMT2C_HUMAN (5-646): 3.67e-10: 66.1: 7.94		HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58
+	Hs
		554279 MUC1_HUMAN (9-367): 1e-15: 83.8: 12.22		PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35
+	Hs
		740556 KMT2C_HUMAN (5-646): 3.67e-10: 66.1: 7.94		PPARG_HUMAN (55-546): 2.12e-100: 316: 20.35
+	Hs
		487596 KMT2C_HUMAN (5-646): 3.67e-10: 66.1: 7.94		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		487681 CHAP1_HUMAN (5-409): 4.66e-10: 65.3: 8.40		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16