HitPredict

Interactor 1: DPOLQ (O75417)
DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 3.6.4.12); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)]
Gene: POLQ

Interactor 2: DPOLQ (O75417)
DNA polymerase theta (DNA polymerase eta) [Includes: Helicase POLQ (EC 3.6.4.12); DNA polymerase POLQ (EC 2.7.7.7) (RNA-directed DNA polymerase POLQ) (EC 2.7.7.49)]
Gene: POLQ

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.54 1.00 0.740

The method score is based on:

Property Details
Experiments 26636256
Identification Methods x-ray crystallography, x ray scattering, cosedimentation in solution, molecular sieving, light scattering
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains DEAD~DEAD, DEAD~Helicase_C, DEAD~HTH_61, DNA_pol_A~DNA_pol_A, Helicase_C~Helicase_C, HTH_61~Helicase_C
Common GO terms GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000287 - magnesium ion binding
GO:0003678 - DNA helicase activity
GO:0003682 - chromatin binding
GO:0003684 - damaged DNA binding
and 21 others

more...
Homologous interactions 11

Homologous interactions

Color coding for hit scores

1 2590
Hs

1 2590
+ Bs
+ Hs
+ Sc
+ Sp
+ Sc
+ Sc
+ Hs
+ Sc
+ Sp
+ Hs
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024