HitPredict

Interactor 1: GGYF1 (O75420)
GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1)
Gene: GIGYF1

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.661

Property	Details
Experiments	12771153, 16037382, 20878056
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0032991 - protein-containing complex GO:0048009 - insulin-like growth factor receptor signaling pathway
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1035 Hs			1 594
+	Hs
		264307 GGYF1_HUMAN (1-1035): 0: 1030: 100.00		GRB14_HUMAN (76-594): 0: 575: 55.08
+	Hs
		264308 GGYF1_HUMAN (1-1035): 0: 1030: 100.00		GRB7_HUMAN (107-594): 1.36e-174: 507: 55.60
+	Mm
		1141344 GGYF1_MOUSE (1-1035): 0: 998: 86.43		GRB10_MOUSE (57-148): 3.15e-14: 77.6: 69.15
+	Hs
		1031678 GGYF2_HUMAN (538-1035): 1.18e-65: 244: 27.03		GRB10_HUMAN (1-594): 0: 712: 100.00
+	Hs
		1054040 GGYF2_HUMAN (538-1035): 1.18e-65: 244: 27.03		GRB14_HUMAN (76-594): 0: 575: 55.08
+	Hs
		1054060 GGYF2_HUMAN (538-1035): 1.18e-65: 244: 27.03		GRB7_HUMAN (107-594): 1.36e-174: 507: 55.60
+	Hs
		1068630 PLEC_HUMAN (511-823): 8.13e-12: 72: 10.90		Q96D37_HUMAN (36-594): 5.45e-140: 427: 14.11
+	Hs
		548710 PLEC_HUMAN (511-823): 8.13e-12: 72: 10.90		VAV_HUMAN (36-594): 3.93e-139: 426: 14.11
+	Mm
		1141343 GGYF2_MOUSE (546-1035): 7.22e-64: 238: 27.18		GRB10_MOUSE (57-148): 3.15e-14: 77.6: 69.15
+	Hs
		924586 PLEC_HUMAN (511-823): 8.13e-12: 72: 10.90		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		924566 DCTN1_HUMAN (329-792): 3.09e-09: 63.5: 13.14		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89