HitPredict

Interactor 1: GGYF1 (O75420)
GRB10-interacting GYF protein 1 (PERQ amino acid-rich with GYF domain-containing protein 1)
Gene: GIGYF1

Interactor 2: GGYF2 (Q6Y7W6)
GRB10-interacting GYF protein 2 (PERQ amino acid-rich with GYF domain-containing protein 2) (Trinucleotide repeat-containing gene 15 protein)
Gene: GIGYF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	27173435, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	GYF~GYF
Common GO terms	GO:0005829 - cytosol GO:0032991 - protein-containing complex GO:0048009 - insulin-like growth factor receptor signaling pathway
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 1035 Hs			1 1299
+	Hs
		264286 GGYF1_HUMAN (1-1035): 0: 1030: 100.00		AFAD_HUMAN (299-880): 8.47e-55: 212: 16.30
+	Hs
		1068688 PLEC_HUMAN (511-823): 8.13e-12: 72: 10.90		RRBP1_HUMAN (111-1298): 2.09e-49: 194: 10.49
+	Hs
		724839 PLEC_HUMAN (511-823): 8.13e-12: 72: 10.90		MYH9_HUMAN (349-1161): 1.1e-19: 98.3: 10.26
+	Hs
		528432 MYH13_HUMAN (491-976): 2.38e-10: 67: 11.61		MYH8_HUMAN (718-1299): 1.14e-20: 101: 10.10
+	Hs
		1068536 PLEC_HUMAN (511-823): 8.13e-12: 72: 10.90		PLEC_HUMAN (324-1292): 6.24e-14: 79.4: 8.88
+	Hs
		1068662 PLEC_HUMAN (511-823): 8.13e-12: 72: 10.90		SLK_HUMAN (753-1031): 1.3e-09: 65: 17.39