HitPredict

Interactor 1: MED24 (O75448)
Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)
Gene: MED24

Interactor 2: CDK8 (P49336)
Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35)
Gene: CDK8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.762

Property	Details
Experiments	24981860, 33961781, 26186194, 26496610, 28514442, 29568061, 10198638, 11867769, 32707033, 10024883, 10882111, 23322298, 23602568, 20098423, unassigned1655
Identification Methods	affinity chromatography technology, proximity labelling technology, biochemical, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016592 - mediator complex
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 989 Hs			1 464
+	Hs
		265360 MED24_HUMAN (1-989): 0: 1590: 100.00		CDK19_HUMAN (1-464): 1.35e-144: 424: 75.90
+	Hs
		73023 MED24_HUMAN (1-989): 0: 1590: 100.00		B4DUB1_HUMAN (152-464): 5.46e-111: 334: 69.52