HitPredict

Interactor 1: MED24 (O75448)
Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)
Gene: MED24

Interactor 2: PPARA (Q07869)
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
Gene: PPARA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	9653119
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 989 Hs			1 468
+	Hs
		265302 MED24_HUMAN (1-989): 0: 1590: 100.00		RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61
+	Hs
		265309 MED24_HUMAN (1-989): 0: 1590: 100.00		PPARG_HUMAN (1-468): 2.71e-112: 342: 54.36
+	Hs
		265291 MED24_HUMAN (1-989): 0: 1590: 100.00		ESR1_HUMAN (11-464): 2.21e-107: 332: 18.30
+	Hs
		265301 MED24_HUMAN (1-989): 0: 1590: 100.00		VDR_HUMAN (102-466): 9.88e-107: 325: 24.69
+	Hs
		265310 MED24_HUMAN (1-989): 0: 1590: 100.00		HNF4A_HUMAN (77-464): 1.45e-103: 318: 22.11
+	Mm
		1142713 MED24_MOUSE (1-989): 0: 1587: 94.24		ERR2_MOUSE (6-465): 2.77e-102: 314: 21.67
+	Hs
		265347 MED24_HUMAN (1-989): 0: 1590: 100.00		ESR2_HUMAN (2-465): 7.16e-99: 308: 17.18