HitPredict

Interactor 1: MED24 (O75448)
Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)
Gene: MED24

Interactor 2: SMAD1 (Q15797)
Mothers against decapentaplegic homolog 1 (MAD homolog 1) (Mothers against DPP homolog 1) (JV4-1) (Mad-related protein 1) (SMAD family member 1) (SMAD 1) (Smad1) (hSMAD1) (Transforming growth factor-beta-signaling protein 1) (BSP-1)
Gene: SMAD1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	12167862
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 989 Hs			1 465
+	Hs
		265356 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD5_HUMAN (2-465): 0: 619: 89.46
+	Hs
		171350 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD9_HUMAN (3-465): 0: 607: 81.29
+	Hs
		265317 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD3_HUMAN (3-465): 0: 556: 59.66
+	Hs
		265330 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD2_HUMAN (3-465): 0: 541: 55.14
+	Hs
		167313 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD7_HUMAN (30-131): 2.89e-25: 109: 32.46