HitPredict

Interactor 1: MED24 (O75448)
Mediator of RNA polymerase II transcription subunit 24 (Activator-recruited cofactor 100 kDa component) (ARC100) (Cofactor required for Sp1 transcriptional activation subunit 4) (CRSP complex subunit 4) (Mediator complex subunit 24) (Thyroid hormone receptor-associated protein 4) (Thyroid hormone receptor-associated protein complex 100 kDa component) (Trap100) (hTRAP100) (Vitamin D3 receptor-interacting protein complex 100 kDa component) (DRIP100)
Gene: MED24

Interactor 2: SMAD5 (Q99717)
Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)
Gene: SMAD5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	27703004
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 989 Hs			1 465
+	Hs
		265331 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD1_HUMAN (3-465): 0: 637: 89.68
+	Hs
		171350 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD9_HUMAN (2-465): 0: 617: 78.54
+	Hs
		265317 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD3_HUMAN (4-465): 0: 550: 58.97
+	Hs
		265330 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD2_HUMAN (4-465): 0: 530: 55.60
+	Hs
		167313 MED24_HUMAN (1-989): 0: 1590: 100.00		SMAD7_HUMAN (31-132): 7.88e-27: 113: 31.58