HitPredict - High confidence protein-protein interactions

Interactor 1: ERN1 (O75460)
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]
Gene: ERN1

Interactor 2: ERN1 (O75460)
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]
Gene: ERN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.931

Property	Details
Experiments	12637535, 16973740, 20798350, 21317875
Identification Methods	pull down, x-ray crystallography, biochemical, affinity chromatography technology, enzymatic study, molecular sieving, anti tag coimmunoprecipitation, cosedimentation in solution, cross-linking study, comigration in non denaturing gel electrophoresis and 1 others more... protein kinase assay
Interaction Type	direct interaction, association, physical association, phosphorylation reaction

Property	Details
Interacting Pfam domains	Pkinase~Pkinase, Pkinase~Ribonuc_2-5A, Ribonuc_2-5A~Ribonuc_2-5A
Common GO terms	GO:0000287 - magnesium ion binding GO:0001935 - endothelial cell proliferation GO:0004521 - RNA endonuclease activity GO:0004674 - protein serine/threonine kinase activity GO:0005161 - platelet-derived growth factor receptor binding and 36 others more... GO:0005524 - ATP binding GO:0005637 - nuclear inner membrane GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005783 - endoplasmic reticulum GO:0005789 - endoplasmic reticulum membrane GO:0006402 - mRNA catabolic process GO:0006468 - protein phosphorylation GO:0016241 - regulation of macroautophagy GO:0019899 - enzyme binding GO:0030544 - Hsp70 protein binding GO:0033120 - positive regulation of RNA splicing GO:0034620 - cellular response to unfolded protein GO:0034976 - response to endoplasmic reticulum stress GO:0035924 - cellular response to vascular endothelial growth factor stimulus GO:0036289 - peptidyl-serine autophosphorylation GO:0036498 - IRE1-mediated unfolded protein response GO:0042803 - protein homodimerization activity GO:0043507 - positive regulation of JUN kinase activity GO:0043531 - ADP binding GO:0046777 - protein autophosphorylation GO:0051082 - unfolded protein binding GO:0051879 - Hsp90 protein binding GO:0070054 - mRNA splicing, via endonucleolytic cleavage and ligation GO:0070059 - intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070301 - cellular response to hydrogen peroxide GO:0071333 - cellular response to glucose stimulus GO:0106310 - protein serine kinase activity GO:1900103 - positive regulation of endoplasmic reticulum unfolded protein response GO:1901142 - insulin metabolic process GO:1904707 - positive regulation of vascular associated smooth muscle cell proliferation GO:1990332 - Ire1 complex GO:1990579 - peptidyl-serine trans-autophosphorylation GO:1990597 - AIP1-IRE1 complex GO:1990604 - IRE1-TRAF2-ASK1 complex GO:1990630 - IRE1-RACK1-PP2A complex
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1	977
Hs

1	977

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Last updated: 15 Jul 2024