HitPredict

Interactor 1: E2F6 (O75461)
Transcription factor E2F6 (E2F-6)
Gene: E2F6

Interactor 2: PCGF2 (P35227)
Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144)
Gene: PCGF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24981860, 11171983
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 281 Hs			1 344
+	Hs
		265610 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		BMI1_HUMAN (1-341): 3.88e-98: 295: 61.40
+	Hs
		265660 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF3_HUMAN (4-230): 3.51e-66: 210: 33.48
+	Hs
		265705 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF1_HUMAN (2-232): 1.01e-61: 199: 35.42
+	Hs
		265707 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47
+	Hs
		1051778 E2F2_HUMAN (3-274): 1.57e-92: 282: 37.42		PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47
+	Hs
		135283 E2F3_HUMAN (7-281): 6.47e-87: 268: 36.10		PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47
+	Hs
		265673 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF5_HUMAN (1-221): 5.43e-53: 177: 31.88
+	Hs
		963679 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47
+	Hs
		265700 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		RING2_HUMAN (4-234): 2.68e-45: 159: 17.49
+	Mm
		222619 E2F6_MOUSE (1-272): 3.68e-95: 283: 87.13		RING2_MOUSE (4-234): 2.19e-45: 159: 17.49
+	Hs
		1071528 E2F5_HUMAN (61-273): 4.61e-72: 226: 34.51		PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47
+	Mm
		1257625 Q8VHT4_MOUSE (37-272): 1.09e-86: 260: 88.14		RING2_MOUSE (4-234): 2.19e-45: 159: 17.49
+	Hs
		1081395 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47
+	Hs
		265636 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		RING1_HUMAN (3-127): 4.75e-28: 114: 23.26
+	Hs
		1050537 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		PCGF6_HUMAN (2-227): 3.54e-58: 193: 35.47
+	Hs
		963597 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		RING1_HUMAN (3-127): 4.75e-28: 114: 23.26
+	Hs
		1050532 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		RING2_HUMAN (4-234): 2.68e-45: 159: 17.49
+	Mm
		996146 TFDP1_MOUSE (4-232): 1.8e-59: 196: 17.30		RING2_MOUSE (4-234): 2.19e-45: 159: 17.49
+	Hs
		1050566 TFDP2_HUMAN (4-232): 2.88e-52: 178: 14.64		RING2_HUMAN (4-234): 2.68e-45: 159: 17.49
+	Hs
		987969 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		RING1_HUMAN (3-127): 4.75e-28: 114: 23.26