HitPredict

Interactor 1: E2F6 (O75461)
Transcription factor E2F6 (E2F-6)
Gene: E2F6

Interactor 2: WDR5 (P61964)
WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein)
Gene: WDR5

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.735

Property	Details
Experiments	27705803, 26186194, 28514442, 24981860, 33961781, 15960975
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II GO:0071339 - MLL1 complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 281 Hs			1 334
+	Hs
		903253 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		903221 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		WDR5_HUMAN (1-334): 2.77e-131: 379: 100.00
+	Hs
		209443 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		PLRG1_HUMAN (2-333): 5.29e-85: 267: 26.05
+	Hs
		1081274 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		SMU1_HUMAN (30-331): 7.66e-39: 145: 28.71
+	Hs
		197029 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		PRP4_HUMAN (244-333): 1.12e-10: 64.2: 19.39
+	Hs
		1050528 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		SNR40_HUMAN (248-333): 6.9e-13: 70.4: 25.29