HitPredict

Interactor 1: E2F6 (O75461)
Transcription factor E2F6 (E2F-6)
Gene: E2F6

Interactor 2: PCGF5 (Q86SE9)
Polycomb group RING finger protein 5 (RING finger protein 159)
Gene: PCGF5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 281 Hs			1 256
+	Hs
		265610 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		BMI1_HUMAN (1-229): 2.24e-57: 187: 30.38
+	Hs
		265611 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF2_HUMAN (1-244): 2.94e-56: 185: 29.13
+	Hs
		265660 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF3_HUMAN (3-255): 1.23e-48: 162: 37.04
+	Hs
		265707 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF6_HUMAN (4-248): 2.54e-43: 151: 32.25
+	Hs
		1051778 E2F2_HUMAN (3-274): 1.57e-92: 282: 37.42		PCGF6_HUMAN (4-248): 2.54e-43: 151: 32.25
+	Hs
		265700 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		RING2_HUMAN (2-252): 1.71e-41: 146: 17.59
+	Hs
		265705 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		PCGF1_HUMAN (4-232): 3.33e-42: 146: 31.06
+	Mm
		222619 E2F6_MOUSE (1-272): 3.68e-95: 283: 87.13		RING2_MOUSE (2-252): 2.64e-41: 146: 17.59
+	Hs
		135283 E2F3_HUMAN (7-281): 6.47e-87: 268: 36.10		PCGF6_HUMAN (4-248): 2.54e-43: 151: 32.25
+	Hs
		963679 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		PCGF6_HUMAN (4-248): 2.54e-43: 151: 32.25
+	Hs
		265636 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		RING1_HUMAN (2-142): 1.22e-34: 129: 20.42
+	Mm
		1257625 Q8VHT4_MOUSE (37-272): 1.09e-86: 260: 88.14		RING2_MOUSE (2-252): 2.64e-41: 146: 17.59
+	Hs
		963597 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		RING1_HUMAN (2-142): 1.22e-34: 129: 20.42
+	Hs
		1071528 E2F5_HUMAN (61-273): 4.61e-72: 226: 34.51		PCGF6_HUMAN (4-248): 2.54e-43: 151: 32.25
+	Hs
		1081395 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		PCGF6_HUMAN (4-248): 2.54e-43: 151: 32.25
+	Hs
		1050537 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		PCGF6_HUMAN (4-248): 2.54e-43: 151: 32.25
+	Hs
		1050532 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		RING2_HUMAN (2-252): 1.71e-41: 146: 17.59
+	Mm
		996146 TFDP1_MOUSE (4-232): 1.8e-59: 196: 17.30		RING2_MOUSE (2-252): 2.64e-41: 146: 17.59
+	Hs
		987969 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		RING1_HUMAN (2-142): 1.22e-34: 129: 20.42
+	Hs
		1050566 TFDP2_HUMAN (4-232): 2.88e-52: 178: 14.64		RING2_HUMAN (2-252): 1.71e-41: 146: 17.59