HitPredict

Interactor 1: E2F6 (O75461)
Transcription factor E2F6 (E2F-6)
Gene: E2F6

Interactor 2: RYBP (Q8N488)
RING1 and YY1-binding protein (Apoptin-associating protein 1) (APAP-1) (Death effector domain-associated factor) (DED-associated factor) (YY1 and E4TF1-associated factor 1)
Gene: RYBP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.753

Property	Details
Experiments	26186194, 28514442, 11171983, 12411495, 33961781, 27705803, 24981860, 22325352
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 281 Hs			1 228
+	Hs
		1051773 E2F2_HUMAN (3-274): 1.57e-92: 282: 37.42		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		135271 E2F3_HUMAN (7-281): 6.47e-87: 268: 36.10		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		265679 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1081316 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		1050521 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00
+	Hs
		1050519 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		YAF2_HUMAN (3-227): 3.24e-55: 176: 52.89
+	Hs
		1050561 TFDP2_HUMAN (4-232): 2.88e-52: 178: 14.64		RYBP_HUMAN (1-228): 2.79e-61: 193: 100.00