HitPredict

Interactor 1: E2F6 (O75461)
Transcription factor E2F6 (E2F-6)
Gene: E2F6

Interactor 2: HDAC2 (Q92769)
Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Gene: HDAC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	27705803, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 281 Hs			1 488
+	Hs
		265642 E2F6_HUMAN (1-281): 2.39e-95: 284: 100.00		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		135246 E2F3_HUMAN (7-281): 6.47e-87: 268: 36.10		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1050524 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		HDAC2_HUMAN (1-488): 0: 707: 100.00
+	Hs
		963612 E2F1_HUMAN (10-273): 3.43e-85: 263: 35.25		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Mm
		140276 E2F1_MOUSE (6-256): 1.09e-77: 243: 35.47		HDAC1_MOUSE (1-443): 0: 645: 90.29
+	Hs
		1038416 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		1038368 TFDP1_HUMAN (4-232): 1.64e-61: 201: 17.72		HDAC1_HUMAN (1-443): 0: 642: 90.07
+	Hs
		177308 E2F4_HUMAN (62-261): 4.28e-67: 216: 34.78		HDAC3_HUMAN (10-431): 0: 574: 58.26