HitPredict

Interactor 1: NR1I2 (O75469)
Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)
Gene: NR1I2

Interactor 2: HS90B (P08238)
Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84) (Heat shock protein family C member 3)
Gene: HSP90AB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	22939624
Identification Methods	luminescence based mammalian interactome mapping, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 434 Hs			1 724
+	Hs
		265845 NR1I2_HUMAN (1-434): 8.86e-124: 368: 100.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Mm
		193208 NR1I3_MOUSE (31-428): 4.29e-106: 319: 38.85		HS90B_MOUSE (1-724): 0: 1089: 99.59
+	Hs
		437840 VDR_HUMAN (19-434): 6.56e-95: 293: 39.49		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438124 NR1H3_HUMAN (16-431): 2.38e-92: 287: 25.60		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		437985 NR2C2_HUMAN (3-434): 1.23e-89: 285: 17.40		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		437901 NR4A1_HUMAN (5-433): 4.39e-89: 284: 21.63		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438091 PPARD_HUMAN (36-430): 2.23e-89: 279: 24.00		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		438177 NR1I3_HUMAN (31-428): 8.13e-89: 275: 40.20		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431801 NR1H3_HUMAN (16-431): 2.38e-92: 287: 25.60		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		368839 ESR1_HUMAN (18-428): 1.96e-84: 271: 19.81		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431647 NR2C2_HUMAN (3-434): 1.23e-89: 285: 17.40		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		437955 PPARG_HUMAN (31-431): 5.85e-84: 267: 24.14		HS90B_HUMAN (1-724): 0: 1086: 100.00
+	Hs
		431759 PPARD_HUMAN (36-430): 2.23e-89: 279: 24.00		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431858 NR1I3_HUMAN (31-428): 8.13e-89: 275: 40.20		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		368832 ESR1_HUMAN (18-428): 1.96e-84: 271: 19.81		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431775 PPARA_HUMAN (5-429): 4e-85: 269: 23.45		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		431608 PPARG_HUMAN (31-431): 5.85e-84: 267: 24.14		HS90A_HUMAN (1-724): 0: 1072: 85.25
+	Hs
		538150 NR2C2_HUMAN (3-434): 1.23e-89: 285: 17.40		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		538103 NR4A1_HUMAN (5-433): 4.39e-89: 284: 21.63		ENPL_HUMAN (3-693): 0: 917: 46.44
+	Hs
		368916 ESR1_HUMAN (18-428): 1.96e-84: 271: 19.81		ENPL_HUMAN (3-693): 0: 917: 46.44