HitPredict

Interactor 1: NR1I2 (O75469)
Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)
Gene: NR1I2

Interactor 2: PRS8 (P62195)
26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)
Gene: PSMC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.481

Property	Details
Experiments	15604093
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 434 Hs			1 406
+	Hs
		509930 VDR_HUMAN (19-434): 6.56e-95: 293: 39.49		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		587150 RXRA_HUMAN (2-428): 2.34e-93: 291: 18.64		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907008 NR1H3_HUMAN (16-431): 2.38e-92: 287: 25.60		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		500362 RARB_HUMAN (7-432): 1.89e-91: 285: 26.57		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		823807 NR2C2_HUMAN (3-434): 1.23e-89: 285: 17.40		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		611412 NR4A1_HUMAN (5-433): 4.39e-89: 284: 21.63		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Mm
		193210 NR1I3_MOUSE (31-428): 4.29e-106: 319: 38.85		PRS6B_MOUSE (1-399): 8.58e-122: 360: 41.86
+	Hs
		906997 PPARD_HUMAN (36-430): 2.23e-89: 279: 24.00		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		487934 RARA_HUMAN (7-432): 1.15e-87: 276: 26.57		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		500475 THB_HUMAN (2-429): 6.98e-88: 276: 25.86		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		907028 NR1I3_HUMAN (31-428): 8.13e-89: 275: 40.20		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		723175 RORA_HUMAN (2-433): 9.58e-86: 273: 19.75		PRS8_HUMAN (1-406): 1.42e-136: 398: 100.00
+	Hs
		823806 NR2C2_HUMAN (3-434): 1.23e-89: 285: 17.40		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		611411 NR4A1_HUMAN (5-433): 4.39e-89: 284: 21.63		PRS4_HUMAN (4-396): 7.85e-130: 382: 46.31
+	Hs
		798611 NR2C2_HUMAN (3-434): 1.23e-89: 285: 17.40		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		798664 NR1I3_HUMAN (31-428): 8.13e-89: 275: 40.20		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		369145 ESR1_HUMAN (18-428): 1.96e-84: 271: 19.81		PRS6B_HUMAN (1-399): 6.4e-122: 361: 41.86
+	Hs
		730213 NR2C2_HUMAN (3-434): 1.23e-89: 285: 17.40		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		369100 ESR1_HUMAN (18-428): 1.96e-84: 271: 19.81		PRS7_HUMAN (84-392): 1.21e-115: 345: 56.31
+	Hs
		823822 NR2C2_HUMAN (3-434): 1.23e-89: 285: 17.40		PRS10_HUMAN (8-101): 2.13e-10: 64: 10.64