HitPredict

Interactor 1: NR1I2 (O75469)
Nuclear receptor subfamily 1 group I member 2 (Orphan nuclear receptor PAR1) (Orphan nuclear receptor PXR) (Pregnane X receptor) (Steroid and xenobiotic receptor) (SXR)
Gene: NR1I2

Interactor 2: UBC9 (P63279)
SUMO-conjugating enzyme UBC9 (EC 2.3.2.-) (RING-type E3 SUMO transferase UBC9) (SUMO-protein ligase) (Ubiquitin carrier protein 9) (Ubiquitin carrier protein I) (Ubiquitin-conjugating enzyme E2 I) (Ubiquitin-protein ligase I) (p18)
Gene: UBE2I

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20719936
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 434 Hs			1 158
+	Hs
		849297 NR1H2_HUMAN (4-431): 7.44e-94: 292: 26.10		UB2D1_HUMAN (4-157): 7.96e-75: 221: 33.12
+	Hs
		874374 NR1H2_HUMAN (4-431): 7.44e-94: 292: 26.10		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		587151 RXRA_HUMAN (2-428): 2.34e-93: 291: 18.64		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		823785 NR2C2_HUMAN (3-434): 1.23e-89: 285: 17.40		UB2D3_HUMAN (4-157): 6.67e-73: 216: 35.07
+	Hs
		130320 NR5A2_HUMAN (6-428): 1.16e-91: 289: 20.25		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		930186 NR1H3_HUMAN (16-431): 2.38e-92: 287: 25.60		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		500407 THA_HUMAN (22-402): 4.56e-90: 283: 25.52		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		823730 NR2C2_HUMAN (3-434): 1.23e-89: 285: 17.40		UB2E1_HUMAN (3-156): 7.23e-67: 203: 33.12
+	Hs
		500477 THB_HUMAN (2-429): 6.98e-88: 276: 25.86		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		782515 HNF4A_HUMAN (13-429): 1.76e-86: 273: 20.00		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		369363 ESR1_HUMAN (18-428): 1.96e-84: 271: 19.81		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		930168 PPARA_HUMAN (5-429): 4e-85: 269: 23.45		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		930249 Q58EY0_HUMAN (34-429): 9.72e-85: 268: 23.01		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Hs
		740497 PPARG_HUMAN (31-431): 5.85e-84: 267: 24.14		UBC9_HUMAN (1-158): 1.43e-70: 211: 100.00
+	Dm
		1181411 Q8WS79_DROME (39-302): 6.61e-21: 96.7: 29.39		Q7KNM2_DROME (1-158): 1.41e-66: 201: 85.44