HitPredict

Interactor 1: FRAT2 (O75474)
GSK-3-binding protein FRAT2 (Frequently rearranged in advanced T-cell lymphomas 2) (FRAT-2)
Gene: FRAT2

Interactor 2: GSK3B (P49841)
Glycogen synthase kinase-3 beta (GSK-3 beta) (EC 2.7.11.26) (Serine/threonine-protein kinase GSK3B) (EC 2.7.11.1)
Gene: GSK3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.879

Property	Details
Experiments	33961781, 23455922, 15522877
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, protein kinase assay, tandem affinity purification
Interaction Type	physical association, phosphorylation reaction, association

Property	Details
Interacting Pfam domains	GSK-3_bind~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0046825 - regulation of protein export from nucleus GO:1904886 - beta-catenin destruction complex disassembly
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 420
+	Hs
		265909 FRAT2_HUMAN (1-233): 3.28e-116: 333: 100.00		GSK3A_HUMAN (21-420): 1.87e-147: 429: 77.75
+	Hs
		835915 FRAT1_HUMAN (1-231): 1.04e-92: 275: 70.23		GSK3B_HUMAN (1-408): 1.15e-162: 465: 100.00
+	Hs
		835476 FRAT1_HUMAN (1-231): 1.04e-92: 275: 70.23		GSK3A_HUMAN (21-420): 1.87e-147: 429: 77.75