HitPredict

Interactor 1: PSIP1 (O75475)
PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)
Gene: PSIP1

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	23508102, 25082813, 18598942
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 3969
+	Hs
		975259 ZMY11_HUMAN (9-318): 6.35e-35: 140: 18.01		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		266073 PSIP1_HUMAN (1-530): 1.2e-79: 260: 100.00		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		266021 PSIP1_HUMAN (1-530): 1.2e-79: 260: 100.00		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		1246387 THOC2_HUMAN (106-366): 2.25e-09: 62.4: 14.59		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		1071484 ZMY11_HUMAN (9-318): 6.35e-35: 140: 18.01		EZH1_HUMAN (3468-3951): 2.87e-107: 364: 18.29
+	Hs
		1071464 ZMY11_HUMAN (9-318): 6.35e-35: 140: 18.01		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		1317717 NSD3_HUMAN (4-445): 6.35e-74: 257: 14.91		NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68
+	Hs
		850929 HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		1080075 HDGR2_HUMAN (1-521): 2.98e-21: 99.5: 20.73		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		331678 NSD2_HUMAN (3-444): 2.88e-58: 211: 13.09		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Mm
		291747 DNM3B_MOUSE (3-196): 2.47e-11: 68.3: 11.17		EZH2_MOUSE (3450-3951): 3.64e-105: 358: 18.54
+	Hs
		1115577 GLYR1_HUMAN (4-215): 5.73e-35: 139: 20.27		NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68
+	Hs
		331751 HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23