HitPredict

Interactor 1: PSIP1 (O75475)
PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)
Gene: PSIP1

Interactor 2: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	0.60	0.578

Property	Details
Experiments	9885563
Identification Methods	far western blotting, affinity chromatography technology, pull down
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000395 - mRNA 5'-splice site recognition GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 248
+	Hs
		331802 NSD2_HUMAN (3-444): 2.88e-58: 211: 13.09		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		331803 NSD2_HUMAN (3-444): 2.88e-58: 211: 13.09		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		516645 NSD1_HUMAN (2-529): 5.98e-69: 243: 11.41		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		331795 NSD2_HUMAN (3-444): 2.88e-58: 211: 13.09		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		1028679 GLYR1_HUMAN (4-215): 5.73e-35: 139: 20.27		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		1028940 GLYR1_HUMAN (4-215): 5.73e-35: 139: 20.27		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		993722 ZMY11_HUMAN (9-318): 6.35e-35: 140: 18.01		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		993730 GLYR1_HUMAN (4-215): 5.73e-35: 139: 20.27		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		992785 ZMY11_HUMAN (9-318): 6.35e-35: 140: 18.01		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		992796 GLYR1_HUMAN (4-215): 5.73e-35: 139: 20.27		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		850917 HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Hs
		516529 ZMY11_HUMAN (9-318): 6.35e-35: 140: 18.01		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		850910 HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		951982 GLYR1_HUMAN (4-215): 5.73e-35: 139: 20.27		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		1084288 GLYR1_HUMAN (4-215): 5.73e-35: 139: 20.27		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		850900 HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Hs
		850931 HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Mm
		857320 HDGR2_MOUSE (1-471): 9.26e-19: 91.8: 21.29		TIA1_MOUSE (115-203): 5.51e-10: 60.8: 11.70