HitPredict

Interactor 1: PSIP1 (O75475)
PC4 and SFRS1-interacting protein (CLL-associated antigen KW-7) (Dense fine speckles 70 kDa protein) (DFS 70) (Lens epithelium-derived growth factor) (Transcriptional coactivator p75/p52)
Gene: PSIP1

Interactor 2: HDGR2 (Q7Z4V5)
Hepatoma-derived growth factor-related protein 2 (HDGF-related protein 2) (HRP-2) (Hepatoma-derived growth factor 2) (HDGF-2)
Gene: HDGFL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 34349018
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	LEDGF~LEDGF, PWWP~PWWP
Common GO terms	GO:0005634 - nucleus GO:0006338 - chromatin remodeling
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 530 Hs			1 671
+	Hs
		1317717 NSD3_HUMAN (4-445): 6.35e-74: 257: 14.91		NSD3_HUMAN (4-413): 2.6e-62: 227: 11.66
+	Hs
		331678 NSD2_HUMAN (3-444): 2.88e-58: 211: 13.09		NSD2_HUMAN (3-440): 5.42e-66: 238: 11.70
+	Hs
		1115577 NSD3_HUMAN (4-445): 6.35e-74: 257: 14.91		GLYR1_HUMAN (6-212): 3.25e-36: 145: 21.10
+	Hs
		850940 HDGF_HUMAN (3-225): 5.03e-24: 102: 38.94		HDGR2_HUMAN (1-671): 9.52e-82: 274: 100.00
+	Hs
		1190745 HDGR3_HUMAN (2-201): 1.42e-23: 100: 44.50		HDGR2_HUMAN (1-671): 9.52e-82: 274: 100.00
+	Hs
		265971 PSIP1_HUMAN (1-530): 1.2e-79: 260: 100.00		HDGF_HUMAN (3-234): 8.81e-26: 108: 35.78
+	Mm
		851010 HDGF_MOUSE (3-237): 7.21e-26: 108: 39.15		HDGR2_MOUSE (1-671): 8.94e-74: 252: 70.34
+	Hs
		331751 NSD2_HUMAN (3-444): 2.88e-58: 211: 13.09		HDGF_HUMAN (3-234): 8.81e-26: 108: 35.78
+	Hs
		517806 GLYR1_HUMAN (4-215): 5.73e-35: 139: 20.27		NFH_HUMAN (4-506): 1.46e-35: 146: 10.52