HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	31527615, unassigned1953
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 595
+	Hs
		370711 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369401 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369424 SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369534 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		368886 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369739 PAP1L_HUMAN (6-99): 1.67e-18: 86.3: 21.28		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		370422 PABP3_HUMAN (2-99): 1.17e-17: 84: 18.37		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		369421 TIAR_HUMAN (5-151): 6.76e-17: 81: 13.91		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		964038 SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1031409 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1119140 PAP1L_HUMAN (6-99): 1.67e-18: 86.3: 21.28		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		1269600 PABP3_HUMAN (2-99): 1.17e-17: 84: 18.37		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		963552 TIAR_HUMAN (5-151): 6.76e-17: 81: 13.91		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		782537 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		HNF4A_HUMAN (146-592): 2.13e-118: 361: 20.58
+	Hs
		611434 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Hs
		516359 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		NR4A1_HUMAN (64-549): 2.81e-105: 331: 24.54
+	Mm
		509289 PABP1_MOUSE (2-99): 6.34e-19: 87.9: 17.35		RARA_MOUSE (81-545): 8.36e-104: 323: 22.37
+	Hs
		487081 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16