HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	29721183
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 215
+	Hs
		449673 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00
+	Hs
		516365 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		HMGB2_HUMAN (1-187): 7e-43: 145: 82.89
+	Hs
		996959 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50
+	Hs
		818011 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91
+	Hs
		817926 TIAR_HUMAN (5-151): 6.76e-17: 81: 13.91		SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91
+	Sc
		376710 PABP_YEAST (2-98): 4.25e-20: 91: 24.74		IXR1_YEAST (79-174): 6.78e-16: 77.4: 23.96
+	Hs
		952089 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		CIC_HUMAN (3-96): 2.76e-12: 67: 22.34
+	Mm
		639837 TIAR_MOUSE (12-108): 8.8e-20: 89.6: 25.77		UBF1_MOUSE (49-203): 2.84e-09: 58.2: 20.25