HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 34316707
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 1 others more... GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 262 Hs			1 372
+	Hs
		453706 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00
+	Hs
		266911 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00
+	Hs
		610108 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00
+	Hs
		453287 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00
+	Hs
		852206 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71
+	Hs
		453331 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00
+	Hs
		453107 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00
+	Hs
		162035 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41
+	Hs
		161948 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41
+	Sc
		376562 PABP_YEAST (2-98): 4.25e-20: 91: 24.74		PABP_YEAST (4-189): 6.12e-39: 147: 24.47
+	Hs
		266976 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98
+	Hs
		1020353 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98
+	Hs
		266989 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00
+	Zm
		9810 B4F8E1_MAIZE (5-181): 1.38e-33: 122: 36.16		A0A1D6EZQ5_MAIZE (7-367): 1.68e-16: 82.5: 22.99
+	Hs
		951937 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98
+	Zm
		73522 B4F8E1_MAIZE (5-181): 1.38e-33: 122: 36.16		B4FMA8_MAIZE (12-106): 1.42e-12: 70.2: 34.38
+	Hs
		1020249 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98
+	Hs
		680437 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		TIA1_HUMAN (99-193): 5.41e-09: 59.4: 17.71
+	Mm
		857332 SRSF2_MOUSE (4-90): 1.89e-24: 99.3: 45.65		TIA1_MOUSE (99-193): 5.17e-09: 59.4: 17.71
+	Mm
		665745 PABP1_MOUSE (2-99): 6.34e-19: 87.9: 17.35		TIA1_MOUSE (99-193): 5.17e-09: 59.4: 17.71