HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: FUS (P35637)
RNA-binding protein FUS (75 kDa DNA-pairing protein) (Oncogene FUS) (Oncogene TLS) (POMp75) (Translocated in liposarcoma protein)
Gene: FUS

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.793

Property	Details
Experiments	10779324, 9774382
Identification Methods	affinity chromatography technology, two hybrid, beta lactamase complementation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 262 Hs			1 526
+	At
		1163067 SL30A_ARATH (9-244): 8.07e-42: 145: 33.48		CYP59_ARATH (205-524): 5.51e-32: 130: 13.45
+	Hs
		727096 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Mm
		882705 SRS10_MOUSE (1-262): 2.41e-34: 126: 100.00		FUS_MOUSE (1-526): 6.91e-34: 136: 86.72
+	Mm
		952207 SRSF3_MOUSE (1-95): 1.17e-25: 100: 35.79		Q8BQ46_MOUSE (42-460): 2.55e-40: 155: 48.34
+	Hs
		726746 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Hs
		967515 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		726795 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		FUS_HUMAN (1-526): 1.99e-39: 152: 100.00
+	Mm
		882688 SRSF2_MOUSE (4-90): 1.89e-24: 99.3: 45.65		FUS_MOUSE (1-526): 6.91e-34: 136: 86.72
+	At
		1163068 SRC33_ARATH (5-244): 1.41e-24: 101: 29.03		CYP59_ARATH (205-524): 5.51e-32: 130: 13.45
+	At
		1093112 SRC28_ARATH (8-187): 1.2e-24: 100: 35.00		CYP59_ARATH (205-524): 5.51e-32: 130: 13.45
+	Hs
		951928 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		963966 SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65		EWS_HUMAN (3-451): 5.13e-31: 129: 31.05
+	Hs
		952176 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		964080 SRSF2_HUMAN (4-90): 1.89e-24: 99.3: 45.65		PPIE_HUMAN (280-514): 1.23e-31: 125: 19.46
+	Hs
		952195 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		RBM8A_HUMAN (219-366): 3.35e-27: 109: 26.35
+	Mm
		1143306 SRSF2_MOUSE (4-90): 1.89e-24: 99.3: 45.65		HTSF1_MOUSE (153-372): 1.7e-23: 106: 16.23
+	Hs
		266904 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		516744 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		516466 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44
+	Hs
		516495 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		PABP1_HUMAN (184-382): 3.08e-12: 71.2: 12.44