HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: CLK2 (P49760)
Dual specificity protein kinase CLK2 (EC 2.7.12.1) (CDC-like kinase 2)
Gene: CLK2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.866

Property	Details
Experiments	28514442, 33961781, 34316707
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016607 - nuclear speck
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 262 Hs			1 499
+	Hs
		833938 SRS12_HUMAN (1-251): 1.31e-38: 137: 46.33		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Hs
		833788 SRS12_HUMAN (1-251): 1.31e-38: 137: 46.33		CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31
+	Hs
		266940 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31
+	Hs
		834087 SRS12_HUMAN (1-251): 1.31e-38: 137: 46.33		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		266942 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		833865 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Hs
		267075 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		CLK4_HUMAN (1-484): 6.72e-136: 402: 55.05
+	Hs
		833711 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		CLK1_HUMAN (1-484): 3.66e-144: 424: 53.31
+	Hs
		516416 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		CLK2_HUMAN (1-499): 1.97e-147: 432: 100.00
+	Hs
		834022 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		834033 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		516417 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		CLK3_HUMAN (1-499): 1.7e-136: 409: 59.32
+	Hs
		267037 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		DYRK2_HUMAN (9-499): 1.04e-115: 355: 22.20
+	Hs
		516362 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		CDK2_HUMAN (160-488): 4.25e-133: 389: 24.70
+	Hs
		1043996 SRS12_HUMAN (1-251): 1.31e-38: 137: 46.33		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		266986 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	At
		847172 SRC33_ARATH (5-244): 1.41e-24: 101: 29.03		AFC2_ARATH (136-483): 6.83e-118: 355: 47.35
+	Zm
		33400 A0A1D6M1U3_MAIZE (5-127): 1.28e-19: 88.5: 27.20		A0A1D6L2E7_MAIZE (43-486): 2.72e-110: 354: 28.16
+	Hs
		951958 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50
+	Hs
		1031320 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		DYR1A_HUMAN (108-485): 6.52e-105: 331: 28.50