HitPredict

Interactor 1: SRS10 (O75494)
Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein)
Gene: SRSF10

Interactor 2: ELAV2 (Q12926)
ELAV-like protein 2 (ELAV-like neuronal protein 1) (Hu-antigen B) (HuB) (Nervous system-specific RNA-binding protein Hel-N1)
Gene: ELAVL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0006355 - regulation of DNA-templated transcription
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 262 Hs			1 359
+	Hs
		1020353 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		ELAV2_HUMAN (1-359): 5.95e-103: 309: 100.00
+	Hs
		951937 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		ELAV2_HUMAN (1-359): 5.95e-103: 309: 100.00
+	Hs
		1020249 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		ELAV2_HUMAN (1-359): 5.95e-103: 309: 100.00
+	Hs
		516484 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		ELAV2_HUMAN (1-359): 5.95e-103: 309: 100.00
+	Hs
		266904 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		PABP1_HUMAN (115-358): 1.39e-44: 164: 20.88
+	Hs
		516744 PPIE_HUMAN (10-98): 5.42e-30: 115: 31.46		PABP1_HUMAN (115-358): 1.39e-44: 164: 20.88
+	Hs
		516466 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		PABP1_HUMAN (115-358): 1.39e-44: 164: 20.88
+	Hs
		516495 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		PABP1_HUMAN (115-358): 1.39e-44: 164: 20.88
+	Hs
		516339 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		PABP1_HUMAN (115-358): 1.39e-44: 164: 20.88
+	Sc
		376562 PABP_YEAST (2-98): 4.25e-20: 91: 24.74		PABP_YEAST (7-286): 2.29e-42: 157: 22.44
+	Hs
		516689 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		PABP3_HUMAN (115-358): 2.14e-42: 157: 20.51
+	Hs
		266998 SRS10_HUMAN (1-262): 2.41e-34: 126: 100.00		RBMS2_HUMAN (32-217): 2.99e-25: 107: 36.27
+	Hs
		668339 SRSF3_HUMAN (1-95): 1.17e-25: 100: 35.79		RBMS1_HUMAN (37-227): 8.76e-27: 111: 36.55
+	Dm
		597062 PABP_DROME (2-99): 4.79e-20: 91: 15.31		SHEP_DROME (37-223): 2.25e-26: 112: 36.36
+	Hs
		668348 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		RBMS1_HUMAN (37-227): 8.76e-27: 111: 36.55
+	Hs
		516371 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		RBMS1_HUMAN (37-227): 8.76e-27: 111: 36.55
+	Hs
		516532 PABP1_HUMAN (2-99): 5.61e-19: 87.9: 17.35		RBMS2_HUMAN (32-217): 2.99e-25: 107: 36.27
+	Mm
		936671 SRSF3_MOUSE (1-95): 1.17e-25: 100: 35.79		ELAV1_MOUSE (24-120): 1.54e-17: 84.3: 29.90
+	Hs
		1031344 PABP4_HUMAN (2-99): 3.59e-20: 91.3: 18.37		ELAV1_HUMAN (24-120): 1.32e-17: 84.3: 29.90