HitPredict

Interactor 1: TNR21 (O75509)
Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
Gene: TNFRSF21

Interactor 2: TRADD (Q15628)
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TNFR1-associated DEATH domain protein) (TNFRSF1A-associated via death domain)
Gene: TRADD

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	9714541, 24374337
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Death~Death
Common GO terms	GO:0005886 - plasma membrane GO:0006915 - apoptotic process GO:0071356 - cellular response to tumor necrosis factor
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 655 Hs			1 312
+	Hs
		591336 TNR1B_HUMAN (21-337): 5.78e-62: 215: 24.43		TRADD_HUMAN (1-312): 0: 526: 100.00
+	Mm
		626858 TNR1A_MOUSE (31-335): 3.7e-55: 196: 20.58		TRADD_MOUSE (1-312): 0: 530: 76.60
+	Rn
		88839 TNR1A_RAT (31-335): 1.81e-53: 191: 18.91		D3ZZC5_RAT (1-312): 0: 524: 76.92
+	Hs
		1075526 TNR25_HUMAN (40-315): 1.73e-41: 157: 15.53		TRADD_HUMAN (1-312): 0: 526: 100.00
+	Hs
		584411 TNR1A_HUMAN (31-306): 8.41e-40: 153: 17.06		TRADD_HUMAN (1-312): 0: 526: 100.00
+	Hs
		121485 TR10A_HUMAN (2-169): 4.93e-33: 134: 21.26		TRADD_HUMAN (1-312): 0: 526: 100.00
+	Hs
		154365 TR10B_HUMAN (2-232): 9.43e-33: 133: 20.69		TRADD_HUMAN (1-312): 0: 526: 100.00
+	Hs
		632286 TNR6_HUMAN (43-170): 9.66e-34: 133: 20.46		TRADD_HUMAN (1-312): 0: 526: 100.00
+	Hs
		436625 TNR16_HUMAN (26-137): 1.73e-18: 90.2: 22.32		TRADD_HUMAN (1-312): 0: 526: 100.00