HitPredict

Interactor 1: ECI2 (O75521)
Enoyl-CoA delta isomerase 2 (EC 5.3.3.8) (DRS-1) (Delta(3),delta(2)-enoyl-CoA isomerase) (D3,D2-enoyl-CoA isomerase) (Diazepam-binding inhibitor-related protein 1) (DBI-related protein 1) (Dodecenoyl-CoA isomerase) (Hepatocellular carcinoma-associated antigen 88) (Peroxisomal 3,2-trans-enoyl-CoA isomerase) (pECI) (Renal carcinoma antigen NY-REN-1)
Gene: ECI2

Interactor 2: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	22645313, 29426014
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 394 Hs			1 875
+	Hs
		983113 ECH1_HUMAN (109-391): 5.01e-83: 258: 21.21		UBE3A_HUMAN (1-875): 0: 1058: 100.00
+	Hs
		267435 ECI2_HUMAN (1-394): 3.05e-158: 452: 100.00		ITCH_HUMAN (325-873): 0: 579: 24.78
+	Hs
		671526 ECHM_HUMAN (116-392): 7.54e-95: 287: 20.50		SMUF2_HUMAN (334-872): 0: 554: 24.79
+	Hs
		1022579 ECH1_HUMAN (109-391): 5.01e-83: 258: 21.21		ITCH_HUMAN (325-873): 0: 579: 24.78
+	Hs
		1022529 ECH1_HUMAN (109-391): 5.01e-83: 258: 21.21		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97
+	Hs
		1192126 CDYL2_HUMAN (106-391): 4.26e-76: 246: 34.50		HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97