HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: GLRX3 (O76003)
Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)
Gene: GLRX3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.631

Property	Details
Experiments	30595380, 31527584
Identification Methods	two hybrid, pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 441 Hs			1 335
+	Mm
		1265100 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		TXND5_MOUSE (1-322): 8.53e-51: 175: 16.36
+	Mm
		1265389 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PDIA6_MOUSE (1-251): 3.55e-38: 142: 14.43
+	Mm
		1208158 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		TXNL1_MOUSE (12-258): 7.97e-38: 138: 20.46
+	Hs
		202565 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		TXNL1_HUMAN (12-258): 1.31e-37: 137: 20.08
+	Mm
		498183 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		THIO_MOUSE (13-116): 1.63e-37: 131: 26.92
+	Hs
		268179 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		TXND5_HUMAN (5-115): 4.2e-28: 114: 19.83
+	Mm
		1265549 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DJC10_MOUSE (6-191): 5.79e-20: 92.9: 11.17
+	Hs
		1067770 POC1B_HUMAN (186-440): 4.25e-48: 173: 15.56		PDIA6_HUMAN (1-251): 7.84e-38: 141: 14.78
+	Hs
		202676 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		TXNL1_HUMAN (12-258): 1.31e-37: 137: 20.08
+	Dm
		1369027 FBXW7_DROME (224-441): 2.22e-25: 111: 15.53		Q9VJZ6_DROME (126-332): 7.02e-31: 117: 38.89
+	Hs
		495564 WDR5B_HUMAN (279-439): 2.9e-21: 96.1: 12.27		THIO_HUMAN (13-116): 4.03e-37: 130: 26.92
+	Hs
		792988 LIS1_HUMAN (332-438): 2.37e-14: 76.5: 18.69		PDIA6_HUMAN (1-251): 7.84e-38: 141: 14.78
+	Hs
		903239 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		PDIA6_HUMAN (1-251): 7.84e-38: 141: 14.78
+	Hs
		903226 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		PDIA5_HUMAN (3-214): 7.7e-37: 140: 17.90
+	Hs
		495500 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		THIO_HUMAN (13-116): 4.03e-37: 130: 26.92
+	Hs
		903370 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		TXND5_HUMAN (5-115): 4.2e-28: 114: 19.83
+	Hs
		423198 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		PDIA1_HUMAN (1-113): 3.33e-24: 104: 21.01
+	Hs
		531783 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		PDIA4_HUMAN (1-115): 7.77e-24: 104: 19.67