HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: DDX5 (P17844)
Probable ATP-dependent RNA helicase DDX5 (EC 3.6.4.13) (DEAD box protein 5) (RNA helicase p68)
Gene: DDX5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	24457600, 27338022, 33754075
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 441 Hs			1 614
+	Mm
		1207263 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		Q8BTS0_MOUSE (1-614): 0: 617: 97.89
+	Mm
		1119389 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DDX17_MOUSE (30-612): 0: 536: 66.67
+	Hs
		268206 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Mm
		1194984 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DDX42_MOUSE (16-603): 6.74e-158: 478: 34.52
+	Hs
		268159 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		DDX42_HUMAN (16-603): 3.74e-156: 474: 34.09
+	Hs
		133791 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52
+	Mm
		1143619 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DDX3X_MOUSE (2-556): 1.63e-145: 438: 35.69
+	Hs
		571547 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		DDX5_HUMAN (1-614): 0: 624: 100.00
+	Hs
		571382 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		DDX5_HUMAN (1-614): 0: 624: 100.00
+	Hs
		1271615 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Hs
		1271621 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Hs
		1271679 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Hs
		181721 POC1A_HUMAN (177-440): 1.72e-50: 177: 14.29		DDX3Y_HUMAN (2-556): 1.95e-145: 438: 34.93
+	Hs
		903410 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		DDX17_HUMAN (30-612): 0: 534: 66.83
+	Hs
		134154 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52
+	Hs
		133956 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52
+	Hs
		134246 FBW1B_HUMAN (160-352): 1.57e-12: 71.3: 18.97		DDX3X_HUMAN (2-556): 9.8e-147: 441: 35.52
+	Hs
		903327 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		DDX46_HUMAN (50-477): 3.83e-108: 350: 40.68