HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: SMCA1 (P28370)
Probable global transcription activator SNF2L1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA1) (Nucleosome-remodeling factor subunit SNF2L) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1)
Gene: SMARCA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24457600, 24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0031491 - nucleosome binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 1054
+	Mm
		1161361 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SMCA1_MOUSE (1-1054): 0: 1138: 94.71
+	Mm
		1265290 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SMCA5_MOUSE (73-1051): 0: 1068: 84.88
+	Hs
		229258 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SMCA5_HUMAN (32-1051): 0: 1065: 81.86
+	Hs
		658714 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		SMCA1_HUMAN (1-1054): 0: 1130: 100.00
+	Hs
		658715 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		SMCA1_HUMAN (1-1054): 0: 1130: 100.00
+	Hs
		268053 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CHD3_HUMAN (31-954): 0: 791: 28.94
+	Hs
		268093 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Mm
		57194 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CHD7_MOUSE (3-1046): 0: 788: 26.74
+	Mm
		1161077 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CHD4_MOUSE (29-960): 0: 787: 28.27
+	Hs
		151466 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CHD2_HUMAN (21-1047): 0: 732: 29.60
+	Hs
		267962 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SMCA4_HUMAN (60-913): 0: 686: 31.42
+	Mm
		1111959 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SMCA4_MOUSE (60-836): 0: 663: 35.23
+	Hs
		1059779 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CHD4_HUMAN (29-960): 0: 789: 28.27
+	Hs
		1018633 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		CHD3_HUMAN (31-954): 0: 791: 28.94
+	Hs
		1254435 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CHD6_HUMAN (1-1039): 0: 750: 26.80
+	Hs
		151440 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CHD1_HUMAN (5-1050): 0: 695: 29.33
+	Hs
		847050 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		SMCA4_HUMAN (60-913): 0: 686: 31.42
+	Hs
		151443 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		CHD1_HUMAN (5-1050): 0: 695: 29.33
+	Hs
		847053 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		SMCA4_HUMAN (60-913): 0: 686: 31.42
+	Hs
		267961 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SMCA2_HUMAN (170-669): 1.05e-122: 413: 44.32