HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: HNF4A (P41235)
Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4)
Gene: HNF4A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25391650
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 474
+	Hs
		245574 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		HNF4A_HUMAN (1-474): 0: 542: 100.00
+	Hs
		782550 TAF5_HUMAN (173-441): 4.8e-16: 82.5: 21.19		HNF4A_HUMAN (1-474): 0: 542: 100.00
+	Hs
		268103 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		Q15156_HUMAN (30-382): 3.17e-98: 314: 26.50
+	Hs
		268200 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Mm
		1142707 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		ERR2_MOUSE (9-375): 1.5e-99: 307: 27.37
+	Hs
		245555 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		THA_HUMAN (20-436): 4.49e-97: 302: 23.03
+	Hs
		370377 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37
+	Hs
		488022 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		RARA_HUMAN (9-382): 7.34e-107: 327: 25.06
+	Hs
		1269548 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Hs
		500446 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		THA_HUMAN (20-436): 4.49e-97: 302: 23.03
+	Hs
		369932 WDR5B_HUMAN (279-439): 2.9e-21: 96.1: 12.27		ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37
+	Hs
		370309 TBL1Y_HUMAN (277-439): 5.06e-19: 91.1: 13.33		ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37
+	Hs
		369669 TAF5_HUMAN (173-441): 4.8e-16: 82.5: 21.19		ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37
+	Hs
		370209 THOC3_HUMAN (148-434): 3.97e-16: 81.3: 19.03		ESR1_HUMAN (10-432): 3.46e-112: 345: 21.37
+	Hs
		488008 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		RARA_HUMAN (9-382): 7.34e-107: 327: 25.06
+	Hs
		1269467 TBL1Y_HUMAN (277-439): 5.06e-19: 91.1: 13.33		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Hs
		1269746 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Hs
		1074801 TAF5_HUMAN (173-441): 4.8e-16: 82.5: 21.19		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Hs
		1269364 THOC3_HUMAN (148-434): 3.97e-16: 81.3: 19.03		ESR2_HUMAN (44-374): 2.23e-99: 310: 27.64
+	Mm
		903664 WDR5_MOUSE (335-440): 3.22e-14: 75.3: 15.09		ERR2_MOUSE (9-375): 1.5e-99: 307: 27.37