HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: CUL4A (Q13619)
Cullin-4A (CUL-4A)
Gene: CUL4A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	17041588
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 759
+	Mm
		1111818 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CUL4A_MOUSE (1-759): 0: 977: 95.13
+	Hs
		268076 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Mm
		56800 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CUL4B_MOUSE (10-759): 0: 927: 82.18
+	Hs
		245601 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043114 POC1B_HUMAN (186-440): 4.25e-48: 173: 15.56		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043562 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043469 POC1B_HUMAN (186-440): 4.25e-48: 173: 15.56		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Mm
		1265597 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CUL3_MOUSE (32-759): 0: 813: 38.36
+	Hs
		1043157 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043085 WDR5B_HUMAN (279-439): 2.9e-21: 96.1: 12.27		CUL4A_HUMAN (1-759): 0: 963: 100.00
+	Hs
		1043499 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Mm
		1265637 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CUL1_MOUSE (59-759): 0: 745: 30.55
+	Hs
		268074 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Hs
		1043509 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Hs
		1043441 WDR5B_HUMAN (279-439): 2.9e-21: 96.1: 12.27		CUL4B_HUMAN (10-759): 0: 927: 82.31
+	Mm
		1265521 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CUL2_MOUSE (51-759): 0: 717: 27.26
+	Hs
		1042101 POC1B_HUMAN (186-440): 4.25e-48: 173: 15.56		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1042655 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		CUL3_HUMAN (32-759): 0: 814: 38.23
+	Hs
		1041133 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CUL1_HUMAN (59-759): 0: 745: 30.55
+	Mm
		1257398 FBXW7_MOUSE (219-439): 5.6e-28: 118: 15.32		CUL1_MOUSE (59-759): 0: 745: 30.55