HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.39	0.60	0.484

Property	Details
Experiments	23238014
Identification Methods	anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 913
+	Hs
		245601 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Mm
		56800 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CUL4B_MOUSE (36-913): 0: 1107: 97.28
+	Hs
		1043562 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		1043469 POC1B_HUMAN (186-440): 4.25e-48: 173: 15.56		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		1043499 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		1043509 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Hs
		1043441 WDR5B_HUMAN (279-439): 2.9e-21: 96.1: 12.27		CUL4B_HUMAN (1-913): 0: 1184: 100.00
+	Mm
		1111818 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CUL4A_MOUSE (161-913): 0: 966: 81.96
+	Hs
		268075 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Mm
		1265597 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CUL3_MOUSE (186-913): 0: 852: 37.19
+	Hs
		1043114 POC1B_HUMAN (186-440): 4.25e-48: 173: 15.56		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Mm
		1265637 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CUL1_MOUSE (213-913): 0: 778: 30.16
+	Hs
		268074 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CUL1_HUMAN (213-913): 0: 778: 30.16
+	Hs
		1043157 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Hs
		1043085 WDR5B_HUMAN (279-439): 2.9e-21: 96.1: 12.27		CUL4A_HUMAN (161-913): 0: 955: 81.83
+	Mm
		1265521 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CUL2_MOUSE (205-913): 0: 752: 27.66
+	Hs
		1042101 POC1B_HUMAN (186-440): 4.25e-48: 173: 15.56		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		1042655 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		CUL3_HUMAN (186-913): 0: 853: 37.19
+	Hs
		1041133 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CUL1_HUMAN (213-913): 0: 778: 30.16
+	Mm
		1257398 FBXW7_MOUSE (219-439): 5.6e-28: 118: 15.32		CUL1_MOUSE (213-913): 0: 778: 30.16