HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: CHD4 (Q14839)
Chromodomain-helicase-DNA-binding protein 4 (CHD-4) (EC 3.6.4.12) (ATP-dependent helicase CHD4) (Mi-2 autoantigen 218 kDa protein) (Mi2-beta)
Gene: CHD4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	24457600, 24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 1912
+	Mm
		1161077 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CHD4_MOUSE (1-1900): 0: 1680: 97.80
+	Hs
		268053 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CHD3_HUMAN (23-1905): 0: 1595: 66.89
+	Hs
		1059779 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Hs
		903234 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		CHD4_HUMAN (1-1912): 0: 1719: 100.00
+	Hs
		1018633 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		CHD3_HUMAN (23-1905): 0: 1595: 66.89
+	Hs
		1018714 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		CHD3_HUMAN (23-1905): 0: 1595: 66.89
+	Mm
		57194 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CHD7_MOUSE (3-1678): 0: 817: 23.03
+	Mm
		1161361 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SMCA1_MOUSE (557-1597): 0: 798: 27.05
+	Mm
		1265290 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SMCA5_MOUSE (601-1624): 0: 795: 26.39
+	Hs
		229258 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SMCA5_HUMAN (578-1624): 0: 791: 26.01
+	Hs
		267906 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SMCA1_HUMAN (617-1597): 0: 779: 27.44
+	Hs
		151466 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CHD2_HUMAN (493-1689): 0: 739: 30.57
+	Hs
		1254435 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CHD6_HUMAN (279-1685): 0: 782: 24.76
+	Hs
		658714 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		SMCA1_HUMAN (617-1597): 0: 779: 27.44
+	Hs
		658715 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		SMCA1_HUMAN (617-1597): 0: 779: 27.44
+	Hs
		151440 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		CHD1_HUMAN (491-1733): 0: 734: 27.99
+	Hs
		1309165 TBL1Y_HUMAN (277-439): 5.06e-19: 91.1: 13.33		CHD8_HUMAN (489-1678): 0: 752: 28.31
+	Hs
		151443 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		CHD1_HUMAN (491-1733): 0: 734: 27.99
+	Hs
		903535 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		CHD8_HUMAN (489-1678): 0: 752: 28.31
+	Hs
		151460 FBW1B_HUMAN (160-352): 1.57e-12: 71.3: 18.97		CHD1_HUMAN (491-1733): 0: 734: 27.99