HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: NUMA1 (Q14980)
Nuclear mitotic apparatus protein 1 (Nuclear matrix protein-22) (NMP-22) (Nuclear mitotic apparatus protein) (NuMA protein) (SP-H antigen)
Gene: NUMA1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	24457600, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 2115
+	Hs
		1061201 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Hs
		1061204 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		NUMA1_HUMAN (1-2115): 1.36e-162: 555: 100.00
+	Mm
		1257473 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		MYH9_MOUSE (1089-2070): 6.61e-40: 165: 12.96
+	Mm
		1265608 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PLEC_MOUSE (21-1207): 2.95e-35: 150: 12.47
+	Hs
		267922 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		267923 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34
+	Hs
		268102 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37
+	Mm
		1143172 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		MYH10_MOUSE (5-834): 3.93e-31: 136: 11.65
+	Mm
		1208628 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CROCC_MOUSE (1-994): 7.74e-27: 122: 12.56
+	Hs
		267867 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04
+	Mm
		93875 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		E9QPE7_MOUSE (1396-1867): 9.42e-16: 86.2: 13.90
+	Hs
		728492 POC1A_HUMAN (177-440): 1.72e-50: 177: 14.29		MYH11_HUMAN (1430-2076): 4.75e-22: 107: 8.41
+	Hs
		724952 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		MYH9_HUMAN (1033-1891): 1.22e-33: 145: 10.62
+	Hs
		725215 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		MYH10_HUMAN (1281-2075): 5.26e-33: 142: 12.34
+	Hs
		1068625 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		PLEC_HUMAN (45-1230): 3.46e-32: 140: 13.37
+	Hs
		792973 LIS1_HUMAN (332-438): 2.37e-14: 76.5: 18.69		CENPE_HUMAN (694-2076): 2.24e-41: 170: 9.63
+	Hs
		1067456 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		EEA1_HUMAN (964-1838): 2.18e-28: 127: 12.15
+	Mm
		925837 LIS1_MOUSE (332-438): 2.21e-14: 76.5: 18.69		Q155P7_MOUSE (562-1890): 5.59e-30: 133: 11.42
+	Hs
		903233 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		GOGB1_HUMAN (1105-2077): 1.12e-19: 99.3: 9.49
+	Hs
		518846 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		TPR_HUMAN (2-620): 2.42e-18: 94.7: 12.04