HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: DDB1 (Q16531)
DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
Gene: DDB1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.759

Property	Details
Experiments	17041588, 23238014
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 441 Hs			1 1140
+	Mm
		1112293 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DDB1_MOUSE (1-1140): 0: 1422: 99.65
+	Hs
		245605 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1082374 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1082327 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1082263 WDR5B_HUMAN (279-439): 2.9e-21: 96.1: 12.27		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		1082480 WSB1_HUMAN (162-437): 7.57e-17: 84: 21.35		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		903254 WDR5_HUMAN (335-440): 3.22e-14: 75.3: 15.09		DDB1_HUMAN (1-1140): 0: 1424: 100.00
+	Hs
		268108 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		SF3B3_HUMAN (3-1126): 0: 1102: 21.33
+	Mm
		1265380 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		SF3B3_MOUSE (3-1126): 0: 1100: 21.33
+	Hs
		1073094 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		SF3B3_HUMAN (3-1126): 0: 1102: 21.33
+	Hs
		1073168 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		SF3B3_HUMAN (3-1126): 0: 1102: 21.33
+	Hs
		268047 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87
+	Mm
		1265562 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		CPSF1_MOUSE (4-527): 7.61e-116: 394: 16.06
+	Hs
		1014208 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87
+	Hs
		1014128 TAF5_HUMAN (173-441): 4.8e-16: 82.5: 21.19		CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87
+	Hs
		197009 PRP4_HUMAN (337-437): 3.12e-09: 60.7: 16.51		CPSF1_HUMAN (4-527): 4.39e-117: 397: 15.87