HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: RING2 (Q99496)
E3 ubiquitin-protein ligase RING2 (EC 2.3.2.27) (Huntingtin-interacting protein 2-interacting protein 3) (HIP2-interacting protein 3) (Protein DinG) (RING finger protein 1B) (RING1b) (RING finger protein 2) (RING finger protein BAP-1) (RING-type E3 ubiquitin transferase RING2)
Gene: RNF2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	24457600, 23238014
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 336
+	Mm
		1265453 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		RING2_MOUSE (1-336): 4.78e-112: 330: 99.70
+	Mm
		1206589 TBL1R_MOUSE (4-335): 1.66e-56: 196: 11.40		RING2_MOUSE (1-336): 4.78e-112: 330: 99.70
+	Hs
		1304089 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Mm
		193413 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		RING1_MOUSE (6-336): 1.23e-70: 227: 51.49
+	Hs
		268040 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		RING1_HUMAN (6-336): 8.6e-69: 222: 51.24
+	Mm
		1246746 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PCGF1_MOUSE (28-336): 2.77e-47: 162: 16.56
+	Hs
		268253 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		PCGF1_HUMAN (28-336): 1.84e-47: 162: 16.88
+	Hs
		1281338 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		RING2_HUMAN (1-336): 4.99e-112: 330: 100.00
+	Hs
		267917 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		BMI1_HUMAN (34-332): 4.13e-45: 158: 15.51
+	Mm
		639477 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		BMI1_MOUSE (34-332): 1.69e-44: 156: 15.23
+	Hs
		267918 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		PCGF2_HUMAN (34-332): 8.08e-44: 155: 16.89
+	Mm
		620792 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PCGF2_MOUSE (34-332): 2.29e-41: 149: 15.56
+	Mm
		1112808 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PCGF5_MOUSE (34-334): 1.96e-41: 146: 14.76
+	Hs
		268265 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		PCGF6_HUMAN (29-296): 6.61e-39: 142: 14.76
+	Mm
		1265430 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		PCGF6_MOUSE (26-296): 1.67e-36: 136: 14.23
+	Hs
		267929 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		749840 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79
+	Hs
		585027 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		RO52_HUMAN (36-286): 4.69e-43: 156: 13.55
+	Hs
		1019346 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		TRI26_HUMAN (36-282): 9.9e-36: 137: 17.90
+	Hs
		749764 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		BRCA1_HUMAN (36-214): 1.15e-33: 133: 25.79