HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: MTA3 (Q9BTC8)
Metastasis-associated protein MTA3
Gene: MTA3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	MTA_R1~WD40
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 594
+	Mm
		1265395 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		MTA3_MOUSE (1-586): 0: 683: 94.20
+	Hs
		268070 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		MTA1_HUMAN (1-586): 0: 627: 69.14
+	Mm
		1225268 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		MTA1_MOUSE (1-586): 0: 625: 68.81
+	Mm
		1265631 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		MTA2_MOUSE (1-584): 0: 613: 64.57
+	Hs
		267823 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		MTA2_HUMAN (1-584): 0: 611: 64.40
+	Hs
		1031923 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		MTA1_HUMAN (1-586): 0: 627: 69.14
+	Hs
		245652 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		NCOR2_HUMAN (53-566): 2.01e-95: 322: 14.10
+	Hs
		245648 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		RCOR1_HUMAN (148-567): 3.74e-78: 257: 16.63
+	Ce
		998284 WDR51_CAEEL (181-441): 5.7e-47: 167: 17.11		EGL27_CAEEL (3-491): 3.99e-100: 330: 22.35
+	Hs
		1288413 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		NCOR2_HUMAN (53-566): 2.01e-95: 322: 14.10
+	Hs
		1309170 TBL1Y_HUMAN (277-439): 5.06e-19: 91.1: 13.33		NCOR2_HUMAN (53-566): 2.01e-95: 322: 14.10
+	Hs
		1346974 NLE1_HUMAN (4-124): 2.95e-18: 88.8: 9.09		NCOR2_HUMAN (53-566): 2.01e-95: 322: 14.10
+	Xl
		1186358 TB1RA_XENLA (279-439): 2.07e-18: 89.2: 14.11		NCOR1_XENLA (53-563): 3.82e-85: 292: 10.75
+	Hs
		1281467 FBXW7_HUMAN (219-439): 1.18e-27: 118: 15.32		RCOR1_HUMAN (148-567): 3.74e-78: 257: 16.63
+	Hs
		245548 TBL1X_HUMAN (13-441): 1.12e-73: 243: 11.39		NCOR1_HUMAN (267-577): 2.53e-09: 62.7: 11.54
+	Hs
		1162164 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		MDEAS_HUMAN (142-457): 8.31e-49: 185: 14.82
+	Hs
		261584 TBL1R_HUMAN (4-335): 2.6e-56: 195: 11.40		NCOR1_HUMAN (267-577): 2.53e-09: 62.7: 11.54
+	Hs
		261563 SNR40_HUMAN (298-441): 8.27e-22: 98: 14.29		NCOR1_HUMAN (267-577): 2.53e-09: 62.7: 11.54
+	Hs
		261578 TBL1Y_HUMAN (277-439): 5.06e-19: 91.1: 13.33		NCOR1_HUMAN (267-577): 2.53e-09: 62.7: 11.54
+	Xl
		1093463 TB1RA_XENLA (279-439): 2.07e-18: 89.2: 14.11		Q1W3Z6_XENLA (266-584): 2.08e-09: 63.1: 7.48