HitPredict

Interactor 1: EED (O75530)
Polycomb protein EED (hEED) (Embryonic ectoderm development protein) (WD protein associating with integrin cytoplasmic tails 1) (WAIT-1)
Gene: EED

Interactor 2: DNM3B (Q9UBC3)
DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)
Gene: DNMT3B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.635

Property	Details
Experiments	16357870, 22094255
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 441 Hs			1 853
+	Mm
		291751 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DNM3B_MOUSE (1-853): 0: 1226: 81.38
+	Mm
		291737 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DNM3A_MOUSE (30-852): 0: 1148: 50.36
+	Hs
		268353 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		DNM3A_HUMAN (30-852): 0: 1126: 49.82
+	Mm
		1265477 EED_MOUSE (1-441): 2.11e-92: 287: 100.00		DNM3L_MOUSE (417-757): 8.49e-157: 466: 36.34
+	Hs
		268231 EED_HUMAN (1-441): 2.11e-92: 287: 100.00		PWP2A_HUMAN (45-310): 1.4e-63: 230: 19.50