HitPredict

Interactor 1: SF3B1 (O75533)
Splicing factor 3B subunit 1 (Pre-mRNA-splicing factor SF3b 155 kDa subunit) (SF3b155) (Spliceosome-associated protein 155) (SAP 155)
Gene: SF3B1

Interactor 2: ESR1 (P03372)
Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)
Gene: ESR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	23403292, 21182205
Identification Methods	affinity chromatography technology, cosedimentation through density gradient
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006338 - chromatin remodeling GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1304 Hs			1 595
+	Hs
		268586 SF3B1_HUMAN (1-1304): 0: 1351: 100.00		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16
+	Hs
		369056 2AAA_HUMAN (496-1043): 1.11e-28: 125: 14.24		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		370122 GCN1_HUMAN (484-1290): 6.88e-28: 125: 15.65		ESR1_HUMAN (1-595): 0: 599: 100.00
+	Hs
		672225 2AAA_HUMAN (496-1043): 1.11e-28: 125: 14.24		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		320174 2AAA_HUMAN (496-1043): 1.11e-28: 125: 14.24		ERR2_HUMAN (92-547): 4.3e-116: 354: 34.86
+	Hs
		1270066 PCLO_HUMAN (113-493): 3.97e-09: 63.8: 9.85		ESR2_HUMAN (26-582): 8.89e-136: 408: 45.88
+	Hs
		487628 GCN1_HUMAN (484-1290): 6.88e-28: 125: 15.65		ANDR_HUMAN (172-455): 8.95e-37: 148: 30.16