HitPredict

Interactor 1: STX11 (O75558)
Syntaxin-11
Gene: STX11

Interactor 2: STXB1 (P61764)
Syntaxin-binding protein 1 (MUNC18-1) (N-Sec1) (Protein unc-18 homolog 1) (Unc18-1) (Protein unc-18 homolog A) (Unc-18A) (p67)
Gene: STXBP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.920

Property	Details
Experiments	25416956, 25910212, 28514442, 33961781
Identification Methods	two hybrid, affinity chromatography technology, two hybrid prey pooling approach, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Sec1~Syntaxin
Common GO terms	GO:0000149 - SNARE binding GO:0005886 - plasma membrane GO:0006886 - intracellular protein transport GO:0048787 - presynaptic active zone membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 287 Hs			1 594
+	Bt
		699167 STX1A_BOVIN (1-286): 1.03e-71: 224: 28.67		STXB1_BOVIN (1-594): 0: 680: 100.00
+	Mm
		139528 STX1A_MOUSE (1-286): 2.38e-71: 223: 28.67		STXB1_MOUSE (1-594): 0: 680: 100.00
+	Mm
		139543 STX1B_MOUSE (1-286): 1.32e-71: 223: 32.17		STXB1_MOUSE (1-594): 0: 680: 100.00
+	Rn
		699173 STX1A_RAT (1-286): 3.02e-71: 223: 28.67		STXB1_RAT (1-594): 0: 680: 100.00
+	Rn
		898824 STX1B_RAT (1-286): 1.32e-71: 223: 32.17		STXB1_RAT (1-594): 0: 680: 100.00
+	Hs
		898829 STX1B_HUMAN (1-286): 1.32e-71: 223: 32.17		STXB1_HUMAN (1-594): 0: 680: 100.00
+	Hs
		901790 STX1A_HUMAN (1-286): 2.81e-70: 220: 28.67		STXB1_HUMAN (1-594): 0: 680: 100.00
+	Hs
		699253 STX2_HUMAN (1-286): 7.63e-68: 214: 31.82		STXB1_HUMAN (1-594): 0: 680: 100.00
+	Rn
		838509 STX2_RAT (1-278): 5.79e-65: 206: 32.37		STXB1_RAT (1-594): 0: 680: 100.00
+	Mm
		192851 STX1A_MOUSE (1-286): 2.38e-71: 223: 28.67		STXB2_MOUSE (1-593): 0: 659: 62.80
+	Hs
		699262 STX2_HUMAN (1-286): 7.63e-68: 214: 31.82		STXB2_HUMAN (1-593): 0: 658: 63.47
+	Rn
		699178 STX1A_RAT (1-286): 3.02e-71: 223: 28.67		STXB2_RAT (1-593): 0: 647: 62.35
+	Hs
		901776 STX4_HUMAN (1-286): 1.54e-58: 190: 27.53		STXB1_HUMAN (1-594): 0: 680: 100.00
+	Hs
		269420 STX11_HUMAN (1-287): 1.26e-63: 203: 100.00		STXB2_HUMAN (1-593): 0: 658: 63.47
+	Rn
		838510 STX2_RAT (1-278): 5.79e-65: 206: 32.37		STXB2_RAT (1-593): 0: 647: 62.35
+	Dm
		991124 STX1A_DROME (10-286): 7.18e-68: 214: 26.72		ROP_DROME (4-589): 0: 623: 62.67
+	Ce
		183451 STX1A_CAEEL (2-286): 5e-66: 209: 28.42		UNC18_CAEEL (4-590): 0: 603: 58.11
+	Hs
		119613 STX2_HUMAN (1-286): 7.63e-68: 214: 31.82		STXB3_HUMAN (1-593): 0: 584: 50.59
+	Hs
		119633 STX4_HUMAN (1-286): 1.54e-58: 190: 27.53		STXB3_HUMAN (1-593): 0: 584: 50.59
+	Dm
		1096639 STX1A_DROME (10-286): 7.18e-68: 214: 26.72		SLY1_DROME (5-586): 5.16e-142: 427: 13.77