HitPredict

Interactor 1: STX11 (O75558)
Syntaxin-11
Gene: STX11

Interactor 2: VTI1A (Q96AJ9)
Vesicle transport through interaction with t-SNAREs homolog 1A (Vesicle transport v-SNARE protein Vti1-like 2) (Vti1-rp2)
Gene: VTI1A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000149 - SNARE binding GO:0005484 - SNAP receptor activity GO:0005794 - Golgi apparatus GO:0006886 - intracellular protein transport GO:0008021 - synaptic vesicle and 1 others more... GO:0031201 - SNARE complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 287 Hs			1 217
+	Hs
		151576 STX1A_HUMAN (1-286): 2.81e-70: 220: 28.67		GOSR2_HUMAN (5-212): 2.08e-53: 172: 14.09
+	Ce
		183452 STX1A_CAEEL (2-286): 5e-66: 209: 28.42		GOSR2_CAEEL (5-216): 8.53e-54: 173: 18.52
+	Dm
		1098112 STX1A_DROME (10-286): 7.18e-68: 214: 26.72		Q9W0N6_DROME (3-214): 2.01e-50: 165: 36.53
+	Dm
		1098107 STX1A_DROME (10-286): 7.18e-68: 214: 26.72		GOSR2_DROME (5-212): 3.58e-50: 164: 18.14
+	Hs
		1084006 STX1A_HUMAN (1-286): 2.81e-70: 220: 28.67		VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80
+	Mm
		292714 Q8BH40_MOUSE (56-286): 1.54e-50: 169: 14.96		VTI1A_MOUSE (1-217): 8.09e-66: 204: 94.93
+	Hs
		699289 STX2_HUMAN (1-286): 7.63e-68: 214: 31.82		VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80
+	Hs
		152170 STX16_HUMAN (13-276): 1.14e-49: 168: 16.17		VTI1A_HUMAN (1-217): 2.21e-63: 197: 100.00
+	Hs
		151566 STX4_HUMAN (1-286): 1.54e-58: 190: 27.53		GOSR2_HUMAN (5-212): 2.08e-53: 172: 14.09
+	Hs
		269494 STX11_HUMAN (1-287): 1.26e-63: 203: 100.00		VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80
+	At
		1352078 SYP43_ARATH (7-285): 1.33e-45: 158: 12.98		VTI12_ARATH (1-215): 8.91e-62: 193: 28.51
+	At
		249589 SYP41_ARATH (7-285): 2.04e-45: 157: 11.93		VTI12_ARATH (1-215): 8.91e-62: 193: 28.51
+	At
		1352079 SYP42_ARATH (10-286): 8.53e-45: 156: 14.29		VTI12_ARATH (1-215): 8.91e-62: 193: 28.51
+	Hs
		1017838 STX4_HUMAN (1-286): 1.54e-58: 190: 27.53		VTI1B_HUMAN (2-216): 3.26e-47: 157: 27.80
+	At
		1352080 SYP43_ARATH (7-285): 1.33e-45: 158: 12.98		VTI11_ARATH (1-216): 4.44e-60: 189: 32.13
+	At
		249590 SYP41_ARATH (7-285): 2.04e-45: 157: 11.93		VTI11_ARATH (1-216): 4.44e-60: 189: 32.13
+	Mm
		1206468 Q8BH40_MOUSE (56-286): 1.54e-50: 169: 14.96		Q91XH6_MOUSE (2-217): 4.06e-54: 174: 29.02
+	Mm
		250839 STX7_MOUSE (56-287): 2.22e-49: 166: 14.89		VTI1B_MOUSE (2-217): 4.1e-54: 174: 29.02
+	Dm
		1098013 STX5_DROME (2-280): 2.25e-43: 155: 12.08		Q9W0N6_DROME (3-214): 2.01e-50: 165: 36.53
+	Dm
		1098008 STX5_DROME (2-280): 2.25e-43: 155: 12.08		GOSR2_DROME (5-212): 3.58e-50: 164: 18.14