HitPredict

Interactor 1: SKAP2 (O75563)
Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid-induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains)
Gene: SKAP2

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1, SH2~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 359 Hs			1 217
+	Hs
		924677 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Mm
		411926 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		LCK_MOUSE (3-202): 2.89e-37: 137: 28.44
+	Hs
		269510 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		411781 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Mm
		763391 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		269511 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		269512 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		269515 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FGR_HUMAN (120-215): 6.83e-13: 68.8: 22.45
+	Hs
		269514 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39
+	Mm
		639444 SKAP2_MOUSE (1-359): 1.56e-121: 356: 90.53		LYN_MOUSE (129-215): 2.66e-11: 64.2: 22.47
+	Hs
		269513 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		269517 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		269519 SKAP2_HUMAN (1-359): 5.4e-121: 355: 100.00		FRK_HUMAN (150-212): 6.98e-11: 62.7: 27.78
+	Hs
		924640 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		412249 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433867 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		523046 SKAP1_HUMAN (13-359): 1e-98: 298: 42.54		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		411764 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		433388 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		433831 PKHA7_HUMAN (26-316): 3.97e-42: 159: 14.52		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47